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Blood Pressure
Active ingredient: Lisinopril hydrochlorothiazide

Zestoretic - tablets containing 12,5Mg of Hydrochlorothiazide and 10Mg of Lisinopril, as active ingredients. It is hypotensive, vasodilating, natriuretic, cardioprotective medical preparation.The drug is used to treat arterial hypertension, also in order to reduce the risk of cardiovascular disease and mortality in patients with hypertension and left ventricular hypertrophy, manifesting cumulative reduction in the incidence of cardiovascular death, incidence of stroke and myocardial infarction.

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Other names for this medication
Availability: In Stock (119 packs)
Zestoretic 5/12.5mg
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30 Pills $1.56 $46.84 - Add to cart
60 Pills $1.22 $93.33 $72.93 $20.40 Add to cart
90 Pills $1.10 $140.44 $99.04 $41.40 Add to cart
120 Pills $1.06 $187.44 $127.44 $60.00 Add to cart
180 Pills $0.99 $280.58 $177.98 $102.60 Add to cart
270 Pills $0.95 free-shipping $422.18 $257.48 $164.70 Add to cart
360 Pills $0.94 free-shipping $559.86 $336.66 $223.20 Add to cart

Product description

Drug uses

Zestoretic is an oral drug, containing two antihypertensive agents, Lisinopril and Hydrochlorothiazide. Due to the combination of the two active ingredients, Zestoretic has a dual mechanism of action.

  • Lisinopril lowers high arterial pressure by widening blood vessels.
  • Hydrochlorothiazide helps control high blood pressure through diuresis simulation.

Zestoretic is approved for the second-line hypertension treatment in patients, who fail controlling blood pressure with drugs for hypertension monotherapy.

By promoting vasodilation and diuresis, Zestoretic tablets provide a quick, powerful and long-lasting antihypertensive effect.

Taking note of this fact, the patients require regular blood pressure monitoring in early days of Zestoretic treatment. The daily dose of this antihypertensive drug should be reduced, if Zestoretic causes hypotension.

Zestoretic is recommended for once-daily hypertension therapy. The daily Zestoretic dose is one tablet of Zestoretic 10 or Zestoretic 20. Adjustment of antihypertensive therapy is recommended not earlier than 14 days after the starting dose of Zestoretic.

Missed dose

One missed Zestoretic dose does not affect the effectiveness of the antihypertensive therapy. If you missed one dose of Zestoretic, skip it and continue with your normal schedule of this drug use. You should not take more than one Zestoretic 20 pill per day, even if you’ve missed two or more Zestoretic doses in a row.

More information

You should stop using other diuretics and vasodilators before using Zestoretic pills. Zestoretic should be taken with caution by people with moderate or progressive liver disease.


Zestoretic tablets should be stored in a tightly sealed bottle or the original blister packing, at temperature below 30°C. If a blister with Zestoretic pills was removed from the primary packaging, it should be protected from strong light.

Safety information


Using Zestoretic during pregnancy creates a serious threat to the normal fetus development. Therefore, the women of childbearing age should use reliable contraception methods throughout the treatment period with Zestoretic tablets. Zestoretic and other diuretics or vasodilators should be stopped immediately, if you detected pregnancy, when going through the antihypertensive therapy.


Information about the antihypertensive drug Zestoretic is published for general information purposes only. In no event is the online pharmacy liable for any consequences, arising from the use of or restricted access to information about Zestoretic.

Zestoretic side effects

Zestoretic causes undesirable effects very rarely. Clinical studies have demonstrated that approximately 5-7% of patients, taking Zestoretic tablets, have mild headaches or dizziness. Less than 4% of patients may experience fatigue, cough, orthostatic effects, hypotension, when going through treatment with Zestoretic. Zestoretic may rarely cause syncope or muscle cramps.

Just over 4% of the total number of patients, participating in clinical trials for Zestoretic, had to stop taking Zestoretic tablets due to serious unwanted effects. The most frequent reasons for Zestoretic cancellation due to side effects include excessive fatigue, uncontrollable muscle spasm, dizziness, persistent cough.

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